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Gamabufotalin

Cat. No. M14973

All AbMole products are for research use only, cannot be used for human consumption.

Gamabufotalin Structure
Synonym:

Gamabufagin

Size Price Availability Quantity
5mg USD 300 In stock
10mg USD 500 In stock
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Biological Activity

Gamabufotalin (Gamabufagin), a main active compound isolated from Chinese medicine Chansu, has been shown to strongly inhibit cancer cell growth and inflammatory response. Gamabufotalin could inhibite angiogenesis by inhibiting the activation of VEGFR-2 signaling pathways.

Chemical Information
Molecular Weight 402.52
CAS Number 465-11-2
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kaiqiang Sun, et al. Gamabufotalin Inhibits Osteoclastgenesis and Counteracts Estrogen-Deficient Bone Loss in Mice by Suppressing RANKL-Induced NF-κB and ERK/MAPK Pathways

[2] Bo Yuan, et al. Cytotoxic Effects of Arsenite in Combination With Gamabufotalin Against Human Glioblastoma Cell Lines

[3] Kun Ma, et al. Gamabufotalin suppressed osteosarcoma stem cells through the TGF-β/periostin/PI3K/AKT pathway

[4] Yu-Long Lan, et al. Gamabufotalin induces a negative feedback loop connecting ATP1A3 expression and the AQP4 pathway to promote temozolomide sensitivity in glioblastoma cells by targeting the amino acid Thr794

[5] Bo Yuan, et al. Multiple cytotoxic effects of gamabufotalin against human glioblastoma cell line U-87

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