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G3-C12

Cat. No. M22469

All AbMole products are for research use only, cannot be used for human consumption.

G3-C12 Structure
Size Price Availability Quantity
2mg USD 140 In stock
5mg USD 210 In stock
10mg USD 310 In stock
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Biological Activity

G3-C12 is a galectin-3 binding peptide, with Kd of 88 nM, and shows anticancer activity. G3-C12 bearing opolymers N-(2-hydroxypropyl)methacrylamide (HPMA) potently and selectively targets colorectal cancer (CRC) tumour cells over-expressing galectin-3 and displays superior targetability to galectin-3 compared to the galactose bearing copolymer.


Sequence:  Ala-Asn-Thr-Pro-Cys-Gly-Pro-Tyr-Thr-His-Asp-Cys-Pro-Val-Lys-Arg

Chemical Information
Molecular Weight 1758.98
Formula C74H115N23O23S2
CAS Number 848301-94-0
Solubility (25°C) Water 100 mg/mL
Storage -20°C, dry, sealed
References

[1] Xia Yuan, et al. Int J Pharm. Development of (G3-C12)-mediated camptothecin polymeric prodrug targeting to Galectin-3 receptor against androgen-independent prostate cancer

[2] Wei Sun, et al. Mol Pharm. G3-C12 Peptide Reverses Galectin-3 from Foe to Friend for Active Targeting Cancer Treatment

[3] Yang Yang, et al. Mol Pharm. Targeting prostate carcinoma by G3-C12 peptide conjugated N-(2-hydroxypropyl)methacrylamide copolymers

[4] Yang Yang, et al. Biomaterials. Treatment of prostate carcinoma with (galectin-3)-targeted HPMA copolymer-(G3-C12)-5-Fluorouracil conjugates

[5] Kam Leung. 111In-Tetraazacyclododecane- N, N’, N’’, N’’’-tetraacetic acid-(GSG)-ANTPCGPYTHDCPVKR

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Keywords: G3-C12 supplier, Galectin, inhibitors, activators

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