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G-744 

Cat. No. M28212

All AbMole products are for research use only, cannot be used for human consumption.

G-744  Structure

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Quality Control & Documentation
Biological Activity

G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis.

Chemical Information
Molecular Weight 527.64
Formula C29H29N5O3S
CAS Number 1346669-54-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Xiaojing Wang, et al. ACS Med Chem Lett. Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties

[2] Arna Katewa, et al. JCI Insight. Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFN α-driven lupus nephritis

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  Catalog
Abmole Inhibitor Catalog




Keywords: G-744  supplier, BTK, inhibitors, activators

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