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FY-21

Cat. No. M41680

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FY-21 Structure

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Quality Control & Documentation
Biological Activity

FY-21 is a selective inhibitor of LSD1 (IC50=340 nM), with anti-proliferation and anti-colony formation activities.

Chemical Information
Molecular Weight 400.31
Formula C17H15F3N2O6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Soumayah Bachirou et al. Radiat Environ Biophys. Mapping in a radon-prone area in Adamawa region, Cameroon, by measurement of radon activity concentration in soil

[2] Shea Polancich et al. Learn Health Syst. Reducing hospital acquired pressure injury in a learning health center: Making the case for quality

[3] Chao Yang et al. Eur J Med Chem. Discovery of new tetrahydroisoquinolines as potent and selective LSD1 inhibitors for the treatment of MLL-rearranged leukemia

Related Histone demethylase Products
JIB-04

JIB-04 is a selective inhibitor of Jumonji histone demethylase with IC50 values of 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively.

GSK-J1

GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50 of 60 nM towards KDM6B. GSK J1 is selective for the H3K27 demethylases JMJD3 and UTX.

GSK-J4 hydrochloride

GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 hydrochloride is a cell permeable procompound of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM and inactive against a panel of demethylases of the JMJ family.

OG-L002

OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.

GSK-LSD1 dihydrochloride

GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B).

  Catalog
Abmole Inhibitor Catalog




Keywords: FY-21 supplier, Histone demethylase, inhibitors, activators

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