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Furosemide sodium is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema.
| Molecular Weight | 352.73 |
| Formula | C12H10ClN2NaO5S |
| CAS Number | 41733-55-5 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL Water 90 mg/mL |
| Storage | 2-8°C, dry, sealed |
[1] Seahyung Park, et al. Protocol for sodium depletion and measurement of sodium appetite in mice
[2] Niklas Ayasse, et al. ENaC expression correlates with the acute furosemide-induced K + excretion
[3] B M Santos, et al. Reciprocal interactions between sodium appetite and need-free sugar intake
[4] C Y Porcari, et al. Brain osmo-sodium sensitive channels and the onset of sodium appetite
[5] Robert F Lundy Jr, et al. Furosemide, sodium appetite, and ingestive behavior
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