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FTY720 (S)-Phosphate

Cat. No. M14001

All AbMole products are for research use only, cannot be used for human consumption.

FTY720 (S)-Phosphate Structure
Synonym:

(S)-FTY720P; (S)-FTY720 phosphate

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Quality Control & Documentation
Biological Activity

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

*The compound is unstable in solutions, freshly prepared is recommended



Chemical Information
Molecular Weight 387.45
Formula C19H34NO5P
CAS Number 402616-26-6
Form Solid
Solubility (25°C) DMSO 1mg/mL
Storage -20°C
References

[1] Ilaria Callegari, et al. Update on treatment in multiple sclerosis

[2] Reshmi Roy, et al. Sphingosine 1-Phosphate Receptor Modulators for Multiple Sclerosis

[3] Anja Nitzsche, et al. Endothelial S1P 1 Signaling Counteracts Infarct Expansion in Ischemic Stroke

[4] Hideru Obinata, et al. Sphingosine 1-phosphate and inflammation

[5] Lichun Wang, et al. FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury

Related S1P Receptor Products
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Fingolimod (FTY720) HCl is a 1-phospho-neuraminol S1P receptor antagonist with an IC50 of 0.33 nM. , FTY720 can dephosphorylate AMPK by activating PP2A and reduce the expression level of phosphorylated eEF2K, ultimately leading to ADCD and iron death in human multiple myeloma cells.

BAF312

BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors.

SEW2871

SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling.

CYM-5442

CYM-5442 is a potent and selective S1P1 agonist with EC50 of 1.35 nM. CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 can easily penetrate the central nervous system (CNS).

JTE 013

JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.

  Catalog
Abmole Inhibitor Catalog




Keywords: FTY720 (S)-Phosphate, (S)-FTY720P; (S)-FTY720 phosphate supplier, S1P Receptor, inhibitors, activators

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