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FT671 is a potent, non-covalent, selective USP7 inhibitor,IC50 The value is 52 nM, bound to the USP7 catalytic domain Kd The value is 65 nM.
| Molecular Weight | 533.48 |
| Formula | C24H23F4N7O3 |
| CAS Number | 1959551-26-8 |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Deubiquitinase Products |
|---|
| P005091
P005091 (P5091) is a potent and selective inhibitor of ubiquitin-specific protease (USP) 7 with IC50 of 4.2 μM. |
| P22077
P22077 is a selective inhibitor of ubiquitin-specific protease (USP) 7 with EC50 of 8.6 μM. P 22077 also inhibits USP47 with an EC50 of 8.74 μM. |
| b-AP15
b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM. *The compound is unstable in solutions, freshly prepared is recommended |
| PR-619
PR-619 is a broad-spectrum reversible DUB (deubiquitinating enzyme) inhibitor of USP2, USP4, USP5, USP7 and USP8 with an EC50 of 3-9 μM. PR-619 also induces endoplasmic reticulum stress and endoplasmic reticulum stress-associated apoptosis. |
| LDN-57444
LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3. |
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