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Frentizole

Cat. No. M20682

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Frentizole Structure
Synonym:

Frentizol

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Quality Control & Documentation
Biological Activity

Frentizole is a novel inhibitor of amyloid beta peptide (Abeta) binding alcohol dehydrogenase (ABAD) interaction with IC50 of 200 μM. Frentizole is a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus.

Chemical Information
Molecular Weight 299.35
Formula C15H13N3O2S
CAS Number 26130-02-9
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Martha Cecilia Rosales-Hernndez, et al. Molecules. Synthesis and Biological Importance of 2-(thio)ureabenzothiazoles

[2] Lukas Hroch, et al. Bioorg Med Chem. Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment

[3] D R Kay, et al. Arthritis Rheum. Frentizole therapy of active systemic lupus erythematosus

[4] U K Sabharwal, et al. Arthritis Rheum. Frentizole therapy in systemic lupus erythematosus

[5] I I Scheetz ME, et al. Infect Immun. Frentizole, a novel immunosuppressive, and azathioprine: their comparative effects on host resistance to Pseudomonas aeruginosa, Candida albicans, herpes simplex virus, and influenza (Ann Arbor) virus

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Keywords: Frentizole, Frentizol supplier, Amyloid, inhibitors, activators

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