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FQI1

Cat. No. M8334

All AbMole products are for research use only, cannot be used for human consumption.

FQI1 Structure

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Biological Activity

FQI1 inhibits the DNA-binding activity of LSF, a ubiquitous transcription factor that is up regulated in many hepatocellular carcinomas (HCC). FQI1 inhibits LSF-dependent luciferase reporter expression, blocks proliferation in cancer cell lines, and induces apoptosis in liver cancer cells but is not toxic to primary hepatocytes. FQI1 also inhibits tumor growth in a mouse HCC xenograft model.

Chemical Information
Molecular Weight 311.33
Formula C18H17NO4
CAS Number 599151-35-6
Solubility (25°C) DMSO: 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Patrick Stoiber, et al. Factor quinolinone inhibitors alter cell morphology and motility by destabilizing interphase microtubules

[2] Jennifer L S Willoughby, et al. Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence

[3] Patrick Stoiber, et al. Expansile Nanoparticles Encapsulate Factor Quinolinone Inhibitor 1 and Accumulate in Murine Liver upon Intravenous Administration

[4] Olga A Guryanova, et al. FQI1: a transcription-methylation switch for cancer

[5] Hang Gyeong Chin, et al. Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression

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Keywords: FQI1 supplier, inhibitors, activators

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