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Fosmanogepix (APX001) is a first-in-class and orally available broad-spectrum antifungal agent, which targets the highly conserved Gwt1 fungal enzyme. Fosmanogepix (APX001) is an N-phosphonooxymethyl precursor which is rapidly and completely metabolized by systemic alkaline phosphatases to the active moiety, APX001A. Fosmanogepix (APX001) can be used in development for the treatment of invasive fungal infections.
| Molecular Weight | 468.4 |
| Formula | C22H21N4O6P |
| CAS Number | 2091769-17-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 5 mg/mL (ultrasonic and adjust pH to 4 with HCl) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Drew J Winston, et al. Clin Infect Dis. Fosmanogepix Therapy of Disseminated Fusarium Infection
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