All AbMole products are for research use only, cannot be used for human consumption.
Fosciclopirox suppresses growth of urothelial cancer by targeting the γ-secretase complex. Fosciclopirox selectively delivers the active metabolite, Ciclopirox (CPX), to the entire urinary tract. Ciclopirox has anticancer activity in a number of solid and hematologic malignancies.
| Molecular Weight | 317.27 |
| Formula | C13H20NO6P |
| CAS Number | 1380539-06-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL (Need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Gamma-secretase/Beta-secretase Products |
|---|
| DAPT
DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively. DAPT inhibits the activation of Notch 1 signaling. |
| BMS-708163
BMS-708163 (Avagacestat) is a selective γ-secretase inhibitor (IC50 = 0.3 nM). |
| RO4929097
RO4929097 is a potent and selective inhibitor of γ-secretase and as a result is able to inhibit Notch pathway signaling. |
| MK-0752
MK-0752 is a potent, oral inhibitor of γ-secretase with IC50 of 5 nM in human SH-SY5Y cells. |
| LY-411575
LY-411575 is potent and selective small molecule γ-secretase inhibitor with IC50 of 0.1 nM for APP23 and APP51/16 primary neurons. |
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Products are for research use only. Not for human use. We do not sell to patients.
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