All AbMole products are for research use only, cannot be used for human consumption.
Forodesine hydrochloride is a potent and orally active transition-state analog inhibitor of purine nucleoside phosphorylase. Forodesine hydrochloride could induce apoptosis in leukemic cells by increasing the dGTP levels, acts as a potent human lymphocyte proliferation inhibitor.
At a single dose of 10 mg/kg in mice, Forodesine elevates dGuo to approximately 5 μM. In the human peripheral blood lymphocyte severe combined immunodeficiency (hu-PBL-SCID) mouse model, Forodesine is effective in prolonging the life span 2-fold or more.
| Molecular Weight | 302.71 |
| Formula | C11H15ClN4O4 |
| CAS Number | 284490-13-7 |
| Form | Solid |
| Solubility (25°C) | Water 15 mg/mL DMSO 9 mg/mL |
| Storage | -20°C, sealed |
| Related DNA/RNA Synthesis Products |
|---|
| Clofarabine
Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. |
| Gemcitabine Hydrochloride
Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM. |
| Nelarabine
Nelarabine is a novel purine antimetabolite antineoplastic agent. |
| Mizoribine
Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. Mizoribine inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively. |
| Capecitabine
Capecitabine is an orally-administered chemotherapeutic agent. Capecitabine is a precursor, that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. Capecitabine may inhibit cytochrome CYP2C9 enzyme, and therefore increase levels of substrates such as phenytoin and other substrates of CYP2C9. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
