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Fmoc-Val-Cit-PAB-PNP is a cleavable peptide ADC linker which used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by catepsin B. Because this enzyme is only present in the lysosome, the ADC payload will only be released in the cell. The azido group will react with DBCO, BCN or other alkyne groups through click chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.
| Molecular Weight | 766.80 |
| Formula | C40H42N6O10 |
| CAS Number | 863971-53-3 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage | -20°C, protect from light, sealed |
| Related ADC Linker Products |
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| 6-Maleimidohexanoic acid N-hydroxysuccinimide ester
6-Maleimidohexanoic acid N-hydroxysuccinimide ester(ECMS) is a useful protective group in antibody drug conjugates. |
| Sulfo-NHS
Sulfo-NHS is a peptide condensing agent, can form a stable active ester intermediate, used to prepare hydrophilic active ester, for example as a protein cross-linking agent. N-Hydroxysulfosuccinimide (sodium) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
| SPDP Crosslinker
SPDP crosslinker, or SPDP NHS ester, is a cleavable, water insoluble, amino and thiol (sulfhydryl) reactive heterobifunctional protein crosslinker. *The compound is unstable in solutions, freshly prepared is recommended |
| Mc-Val-Cit-PAB
Mc-Val-Cit-PAB is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). |
| Fmoc-Val-Cit-PAB
Fmoc-Val-Cit-PAB-OH is a cleavable useful heterobifunational linker for making Antibody-Drug-Conjugates (ADC). |
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