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FMK is a potent and selective inhibitor of p90 ribosomal protein S6 kinaseRSK2 (wt) with IC50 of 15 nM, >600- and 200-fold selectivity for RSK2 than the C436V and T493M mutants.
| Molecular Weight | 342.37 |
| Formula | C18H19FN4O2 |
| CAS Number | 821794-92-7 |
| Solubility (25°C) | DMSO 10 mM |
| Storage | 2-8℃, dry, sealed |
[3] Nunzia Pagano, et al. Effect of caspase inhibitor Z-VAD-FMK on bovine sperm cryotolerance
[5] Jiaqi Chu, et al. ATG4B inhibitor FMK-9a induces autophagy independent on its enzyme inhibition
| Related S6 Kinase Products |
|---|
| BI-D1870
BI-D1870 is an ATP-competitive, cell permeable and brain penetrated inhibitor of the p90 RSK (ribosomal S6 kinase) with IC50 values of 31 nM, 24 nM, 18 nM, 15 nM for RSK1, RSK2, RSK3, RSK4, respectively. |
| PF-4708671
PF-4708671 is a novel cell-permeable inhibitor of S6K1 with Ki/IC50 value of 20 nM/160 nM. PF4708671 inhibits MSK1 (IC50 of 0.95 μM) 4-fold more weakly than S6K1. |
| SL 0101-1
SL-0101-1 is a selective p90 RSK inhibitor for RSK2 with IC50 of 89 nM. |
| Quercitrin
Quercitrin (Quercitrin) is a natural compound in bitter buckwheat, which has anti-inflammatory effects and has the potential to be used in cardiovascular disease research. |
| LY2584702
LY2584702 is a selective, ATP-competitive p70 S6 kinase inhibitor with IC50 of 4 nM. |
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