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Fluvastatin is the first fully synthesized, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM.Fluvastatin protects vascular smooth muscle cells from oxidative stress through an Nrf2-dependent antioxidant pathway.
| Molecular Weight | 411.47 |
| Formula | C24H26FNO4 |
| CAS Number | 93957-54-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 5 mg/mL |
| Storage | -20°C |
[1] Keitaro Hayashi, et al. Life Sci. Fluvastatin is effective against thymic carcinoma
[2] Päivi Hirvensalo, et al. Clin Pharmacol Ther. Enantiospecific Pharmacogenomics of Fluvastatin
[4] J M Lawrence, et al. Expert Opin Pharmacother. Fluvastatin
| Related HMG-CoA Reductase Products |
|---|
| Fluvastatin sodium
Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor with IC50 value between 40 and 100 nM at human liver microsomes. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. |
| Rosuvastatin calcium
Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions. |
| Mevastatin
Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. |
| Pravastatin sodium
Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. |
| Clinofibrate
Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood. |
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