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Fluocinolone acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor. It is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes.
| Molecular Weight | 452.50 |
| Formula | C24H30F2O6 |
| CAS Number | 67-73-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Daniele Veritti, et al. Fluocinolone acetonide for the treatment of diabetic macular edema
[4] Mark Sanford. Fluocinolone acetonide intravitreal implant (Iluvien®): in diabetic macular oedema
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Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist that induces the production of phospholipase A2 inhibitory protein.It can be used to construct models of allergic conjunctivitis. |
| Budesonide
Budesonide is a synthetic anti-inflammatory glucocorticoid that displays chemopreventive activity. Budesonide is also a DNA methyltransferase activator. |
| AZD5423
AZD5423 is a novel nonsteroidal glucocorticoid receptor agonist. |
| Mometasone furoate
Mometasone furoate is a glucocorticosteroid used topically to reduce inflammation of the skin or in the airways. |
| Hydrocortisone
Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland. |
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