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Flumatinib mesylate is a selective inhibitor of BCR-ABL/PDGFR/c-Kit with IC50s of 1.2 nM, 307.6 nM and 2662 nM, respectively. Flumatinib mesylate can reduce the expression of C-MYC, HIF-1 α and VEGF in U266 cell line in a time- and dose-dependent manners. Flumatinib mesylate inhibits Bcr-Abl autophosphorylation and Stat5 and Erk1/2 phosphorylation. Flumatinib mesylate inhibits tumor growth in chronic myelogenous leukemia model.
| Molecular Weight | 658.69 |
| Formula | C30H33F3N8O4S |
| CAS Number | 895519-91-2 |
| Solubility (25°C) | DMSO 40 mg/mL Water 40 mg/mL |
| Storage | 4°C, dry, sealed |
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