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Flavokawain A

Cat. No. M10756

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Flavokawain A Structure
Synonym:

CAS# 37951-13-6

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25mg USD 40 In stock
50mg USD 50 In stock
100mg USD 80 In stock
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Biological Activity

Flavokawain A is an anticarcinogenic agent, a chalcone found in kava extracts with antitumor activity. Flavokawain A induces apoptosis through Bax protein-dependent and mitochondrial-dependent apoptosis pathways. Flavokawain A has the potential to be used in bladder cancer related research.

Chemical Information
Molecular Weight 314.33
Formula C18H18O5
CAS Number 3420-72-2
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Peramaiyan Rajendran, et al. Toxins (Basel). Anti-Apoptotic Effect of Flavokawain A on Ochratoxin-A-Induced Endothelial Cell Injury by Attenuation of Oxidative Stress via PI3K/AKT-Mediated Nrf2 Signaling Cascade

[2] Hsin-Ling Yang, et al. Oxid Med Cell Longev. Suppression of LPS-Induced Inflammation by Chalcone Flavokawain A through Activation of Nrf2/ARE-Mediated Antioxidant Genes and Inhibition of ROS/NF κ B Signaling Pathways in Primary Splenocytes

[3] Kaili Wang, et al. J Pharm Biomed Anal. Flavokawain A inhibits prostate cancer cells by inducing cell cycle arrest and cell apoptosis and regulating the glutamine metabolism pathway

[4] Lifeng Niu, et al. J Ethnopharmacol. Flavokawain A inhibits Cytochrome P450 in in vitro metabolic and inhibitory investigations

[5] Xiaolin Zi, et al. Cancer Res. Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice

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Keywords: Flavokawain A , CAS# 37951-13-6 supplier, Apoptosis, inhibitors, activators

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