All AbMole products are for research use only, cannot be used for human consumption.
FL118 is a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance. FL118 inhibits human survivinion expression and activates tumor suppressor p53 as a MOA in p53 wild-type cancer cells.
FL118 (10 and 100 nM; 48 h) inhibits PI3K/AKT/mTOR signaling pathway, and affects the expression level of vimentin and E-cadherin in ovarian cancer cells. FL118 (0-500 nM; 24, 48, 72 h) regulates survivin, McL-1, XIAP, cIAP2, c-MYc and mKras by regulating DDX5. FL118 (0-1 μM, 24 h) shows significant cytotoxic activity against the three tumor cell lines (A549, MDA-MB-231, and RM-1 cells).
Int J Mol Sci. 2024 Mar 26;25(7):3693.
FL118 Is a Potent Therapeutic Agent against Chronic Myeloid Leukemia Resistant to BCR-ABL Inhibitors through Targeting RNA Helicase DDX5
FL118 purchased from AbMole
| Molecular Weight | 392.36 |
| Formula | C21H16N2O6 |
| CAS Number | 135415-73-5 |
| Solubility (25°C) | DMSO 1 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related p53 Products |
|---|
| Tenovin-1
Tenovin-1 is a small molecule activator of p53 transcriptional activity. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also a dihydroorotate dehydrogenase (DHODH) inhibitor. |
| Pifithrin-α
Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. |
| JNJ-26854165
JNJ-26854165 (Serdemetan) is a novel activator of p53 capable of inducing apoptosis in cancer cell lines. |
| Inauhzin
Inauhzin is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell). |
| Tenovin-6
Tenovin-6 is a small molecule activator of p53 transcriptional activity. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
