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FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions. FK962 significantly reduces somatostatin-induced inhibition of Ca2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp. FK962 (1 nM-1 μM) also significantly enhances high K+-evoked somatostatin release from rat hippocampal slices.
In vivo, FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats.
| Molecular Weight | 264.3 |
| Formula | C14H17FN2O2 |
| CAS Number | 283167-06-6 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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