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FK614 

Cat. No. M29032

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FK614  Structure

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Quality Control & Documentation
Biological Activity

FK614 is an orally active, non-thiazolidinedione (TZD) type, and selective PPARγ modulator (SPPARM). FK614 functions as a PPARγ agonist with potent anti-diabetic activity in vivo. FK614 has different effects on the activation of PPARγ at each stage of adipocyte differentiation. FK614 can be used for the research of hyperglycemia, hypertriglyceridemia, glucose intolerance and type 2 diabetes.

Chemical Information
Molecular Weight 468.4
Formula C21H23Cl2N3O3S
CAS Number 193012-35-0
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] H Minoura, et al. Diabetes Obes Metab. Mechanism by which a novel non-thiazolidinedione peroxisome proliferator-activated receptor gamma agonist, FK614, ameliorates insulin resistance in Zucker fatty rats

[2] Takao Fujimura, et al. Biol Pharm Bull. Unique properties of coactivator recruitment caused by differential binding of FK614, an anti-diabetic agent, to peroxisome proliferator-activated receptor gamma

[3] Takao Fujimura, et al. J Pharmacol Sci. FK614, a novel peroxisome proliferator-activated receptor gamma modulator, induces differential transactivation through a unique ligand-specific interaction with transcriptional coactivators

[4] Hideaki Minoura, et al. Eur J Pharmacol. Ameliorating effect of FK614, a novel nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist, on insulin resistance in Zucker fatty rat

[5] Hideaki Minoura, et al. Eur J Pharmacol. Pharmacological characteristics of a novel nonthiazolidinedione insulin sensitizer, FK614

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  Catalog
Abmole Inhibitor Catalog




Keywords: FK614  supplier, PPAR, inhibitors, activators

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