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FITC-PBA (Fluorescein Isothiocyanate-Phenylboronic acid) is a functional fluorescent probe molecule obtained by coupling fluorescein isothiocyanate (FITC) with phenylboronic acid (PBA). It finds application in the detection of sugar molecules, analysis of advanced glycation end products, functionalisation of sugar-sensitive nanomaterials, and studies of molecular interactions. The optical properties of FITC-PBA are primarily determined by its fluorescein structure. Its absorption spectrum typically lies around 490–500 nm, with emission peaks occurring between 515–525 nm, exhibiting bright green fluorescence. It possesses high fluorescence intensity and excellent photostability.
Application
Detection of Sugar Molecules and Advanced Glycation End-products
FITC-PBA specifically recognises sugar molecules and advanced glycation end-products (AGEs), enabling quantitative detection via fluorescence signals. It is commonly employed in diabetes research, sugar metabolism analysis, and glycoprotein labelling.
Biosensor Development
Leveraging the sugar selectivity of phenylboronic acid and the FITC fluorescent signal, sugar-sensitive fluorescent sensors can be developed to monitor dynamic changes in blood glucose, monosaccharides, or polysaccharides.
Cell Imaging and Fluorescent Labelling
FITC-PBA binds to cell surface or intracellular glycosylated structures, enabling imaging of cell membrane sugars. Confocal microscopy or flow cytometry enables observation of glycan distribution and metabolic dynamics.
Nanomaterial Functionalisation
FITC-PBA can modify nanoparticles, polymers, or mesoporous materials, achieving dual functions of fluorescent tracking and sugar-specific recognition. This renders it suitable for drug delivery and targeted diagnostic systems.
Molecular Interaction Studies
FITC-PBA facilitates investigation of interactions between glycan molecules and proteins or receptors, monitoring binding kinetics and reaction behaviour through fluorescent signal changes.
Smart Sensor Development
Leveraging the sugar-selective binding properties of phenylboronic acid, FITC-PBA can be integrated into microfluidic chips or optical sensors for online detection and real-time monitoring of glycan molecules.
| Storage | -20°C, protect from light, dry |
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