DOPE (1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) forms heterogenous liposomes with N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP), which are used as delivery vehicles for therapeutic agents. 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) can improve transfection efficiency of naked siRNA.
BioRxiv. 2024 Nov 03;621713.
Machine learning engineered PoLixNano nanoparticles overcome delivery barriers for nebulized mRNA therapeutics
FITC-DOPE purchased from AbMole
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