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FIPI is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM). FIPI prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis.
In vitro: FIPI was added into the Parental CHO cells culture media 1 h before performing an in vivo PLD assay and was found to be a potent inhibitor of PLD2 with an IC50 of 10 nM. PLD1 activity was inhibited even more strongly by FIPI (IC50 = 1 nM).
| Molecular Weight | 421.47 |
| Formula | C23H24FN5O2 |
| CAS Number | 939055-18-2 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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