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Fidarestat

Cat. No. M14297

All AbMole products are for research use only, cannot be used for human consumption.

Fidarestat Structure
Synonym:

SNK 860

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Quality Control & Documentation
Biological Activity

Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.

Chemical Information
Molecular Weight 279.22
CAS Number 136087-85-9
Solubility (25°C) DMSO 150 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Tiangen Wu, et al. Fidarestat induces glycolysis of NK cells through decreasing AKR1B10 expression to inhibit hepatocellular carcinoma

[2] Roshan M Borkar, et al. Identification and characterization of in vitro and in vivo fidarestat metabolites: Toxicity and efficacy evaluation of metabolites

[3] Himangshu Sonowal, et al. Aldose reductase inhibitor, fidarestat prevents doxorubicin-induced endothelial cell death and dysfunction

[4] Feng Dong, et al. Fidarestat improves cardiomyocyte contractile function in db/db diabetic obese mice through a histone deacetylase Sir2-dependent mechanism

[5] Chihiro Hibi. [Fidarestat (SNK-860)]

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Keywords: Fidarestat, SNK 860 supplier, inhibitors, activators

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