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Fevipiprant (QAW039) is a selective, potent, reversible competitive CRTh2 antagonist. NVP-QAW039 displayed high affinity for the human CRTh2 receptor (1.14 ± 0.44 nM) expressed in Chinese hamster ovary cells, the binding being reversible and competitive with the native agonist prostaglandin D2(PGD2). QAW039 was also a potent inhibitor of PGD2-induced cytokine release in human Th2 cells.
| Molecular Weight | 426.41 |
| Formula | C19H17F3N2O4S |
| CAS Number | 872365-14-5 |
| Solubility (25°C) | DMSO: ≥ 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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