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Ferulenol

Cat. No. M40615

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Ferulenol Structure
Size Price Availability
1mg USD 260 3-4 Weeks
5mg USD 620 3-4 Weeks
10mg USD 990 3-4 Weeks
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Biological Activity

Ferulenol is a sesquiterpene-based coumarin derivative isolated and purified from Ferula vesceritensis that causes inhibition of oxidative phosphorylation. At low concentrations, it can inhibit ATP synthesis by inhibiting adenine nucleotide translocase, and has pro-oxidant and anti-cancer activities. In addition, Ferulenol also induces specific inhibition of succinate ubiquinone reductase without altering the succinate dehydrogenase activity of complex II. Ferulenol can be used to study the physiological role of mitochondrial complex II and electron transport mechanisms.

Chemical Information
Molecular Weight 366.49
Formula C24H30O3
CAS Number 6805-34-1
Form Solid
Storage -20°C
References

[1] Augustin Tshibaka Kabongo et al. Front Mol Biosci. Biochemical characterization and identification of ferulenol and embelin as potent inhibitors of malate:quinone oxidoreductase from Campylobacter jejuni

[2] Anuwatchakij Klamrak et al. Molecules. Synthesis of Ferulenol by Engineered Escherichia coli: Structural Elucidation by Using the In Silico Tools

[3] Gilbert Gault et al. Toxicon. Variability of ferulenol and ferprenin concentration in French giant fennel (Ferula sp.) leaves

[4] Nesrine Lariche et al. Anticancer Agents Med Chem. Ferulenol, a Sesquiterpene Coumarin, Induce Apoptosis via Mitochondrial Dysregulation in Lung Cancer Induced by Benzo[a]pyrene: Involvement of Bcl2 Protein

[5] Mesbah Lahouel et al. Biochem Biophys Res Commun. Ferulenol specifically inhibits succinate ubiquinone reductase at the level of the ubiquinone cycle

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Keywords: Ferulenol supplier, Mitochondrial Related, inhibitors, activators

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