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Ferrostatin-1

Cat. No. M2698

All AbMole products are for research use only, cannot be used for human consumption.

Ferrostatin-1 Structure
Synonym:

Fer-1

Size Price Availability Quantity
2mg USD 34 In stock
5mg USD 54 In stock
10mg USD 89 In stock
25mg USD 185 In stock
50mg USD 300 In stock
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Biological Activity

Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. Ferrostatin-1 (2 μM) prevents erastin-induced ferroptosis in cancer cells, as well as glutamate-induced cell death in postnatal rat brain slices. Ferrostatin-1 is a lipid ROS scavenger, with the N-cyclohexyl moiety serving as a lipo-philic anchor within biological membranes. Ferrostatin-1 does not inhibit extracellular signal -regulated kinase (ERK) phos-phorylation or arrest the proliferation of HT-1080 cells, suggesting that it does not inhibit the MEK/ERK pathway, chelate iron, or inhibit protein synthesis. Ferrostatin-1 does, however, prevent erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 readily oxidizes the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) under cell-free conditions.

Product Citations
Protocol (for reference only)
Cell Experiment
Cell lines BEAS-2B cells
Preparation method Cell viability assay
In brief, BEAS-2B cells were seeded into a 96-well plate at the concentration of 5 × 104 cells/well. The cells were cultured for 24 h, then treated with LPS and Fer-1 (M2698) in different concentrations for 16 h followed by the addition of 20 μl of CCK-8 solution directly into the medium (200 μl per well) and incubation at 37 °C for 4 h. The absorbances (Abs) in different groups were detected at 450 nm (n = 3). In the blank group, the well only contained medium, and the cells without any treatment were used as the control group. Herein, the cell viability = (Abs of experimental group-Abs of blank group)/(Abs of control group-Abs of blank group) × 100%.
Concentrations 2 μM
Incubation time 16 h
Animal Experiment
Animal models male C57BL/6 mice
Formulation The Fer-1 was dissolved in DMSO first, and diluted with 0.9% NaCl. The final concentration of Fer-1 and DMSO was 0.2 mg/ml and 0.1% respectively.
Dosages 0.8 mg/kg
Administration via tail vein injection
Chemical Information
Molecular Weight 262.35
Formula C15H22N2O2
CAS Number 347174-05-4
Solubility (25°C) DMSO ≥ 70 mg/mL
Storage -20°C, protect from light, sealed
References

[1] Wanting Shu, et al. Redox Biol. Ferrous but not ferric iron sulfate kills photoreceptors and induces photoreceptor-dependent RPE autofluorescence

[2] Pengfei Liu, et al. Cell Mol Biol Lett. Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis

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Keywords: Ferrostatin-1 , Fer-1 supplier, Ferroptosis, inhibitors, activators

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