All AbMole products are for research use only, cannot be used for human consumption.
Felodipine is widely used to study angina and hypertension. The IC50 of felodipine was ~8 nM, which was about 50 times higher than nifedipine and 430 times higher than verapamil in KCL contractile pig coronary artery segment by blocking Ca2+ channel. Filodipine significantly induced transcription and secretion of IL-6 and IL-8 in human VSMC and lung fibroblasts with ED50 values of 5.8 nM and 5.3 nM, respectively, while propranolol and furosemide did not affect the expression of these two IL-6 genes. Felodipine can block Ca2+ dependent contraction of rat ileum longitudinal smooth muscle (GPILSM) with IC50 of 1.45 nM.
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Male Sprague-Dawley rats with approximately 5/6 renal ablation |
| Formulation | Dissolved in DMSO, and diluted in saline |
| Dosages | 1 g/kg/day |
| Administration | Orally |
| Molecular Weight | 384.25 |
| Formula | C18H19Cl2NO4 |
| CAS Number | 72509-76-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 47 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Calcium Channel Products |
|---|
| KB-R7943 mesylate
KB-R7943 mesylate is a potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = 0.7 mM). |
| Cilnidipine
Cilnidipine is a dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. |
| Azelnidipine
Azelnidipine is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive. Azelnidipine inhibits the intracellular calcium ion flow and lower blood pressure by selectively blocking L-type calcium channel on the membrane of vascular smooth muscle. Azelnidipine inhibits esophageal squamous cell carcinoma proliferation by targeting MEK1/2. Azelnidipine also has anti-inflammatory, antioxidant and neuroprotective effects. |
| Catharanthine
Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM |
| Cinepazide maleate
Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
