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Felcisetrag

Cat. No. M30899

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Felcisetrag Structure
Synonym:

TD-8954

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Quality Control & Documentation
Biological Activity

Felcisetrag (TD-8954) is an orally active, potent and selective 5-HT4 receptor agonist with gastrointestinal prokinetic properties. Felcisetrag has high affinity (pKi =9.4) for human 5-HT4(c) receptors.

Chemical Information
Molecular Weight 455.59
Formula C25H37N5O3
CAS Number 916075-84-8
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Richard Czerniak, et al. J Clin Pharmacol. The Effect of Hepatic Impairment on the Pharmacokinetics of Intravenously Administered Felcisetrag (TAK-954)

[2] Sandeepraj Pusalkar, et al. Eur J Drug Metab Pharmacokinet. Clinical and Nonclinical Disposition and In Vitro Drug-Drug Interaction Potential of Felcisetrag, a Highly Selective and Potent 5-HT4 Receptor Agonist

[3] Chunlin Chen, et al. Clin Pharmacol Drug Dev. Evaluation of the Pharmacokinetics of Felcisetrag (TAK-954), a 5-HT4 Receptor Agonist, in the Presence and Absence of Itraconazole, a Potent CYP3A4 Inhibitor

[4] Benjamin D Rogers, et al. Aliment Pharmacol Ther. Editorial: felcisetrag-forward movement as a novel prokinetic for gastroparesis

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Keywords: Felcisetrag, TD-8954 supplier, 5-HT Receptor, inhibitors, activators

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