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FDW028 is a potent and highly selective FUT8 inhibitor. FDW028 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the CMA pathway. FDW028 acts as a potent therapeutic candidate against mCRC by targeting FUT8, and exhibits potent anti-mCRC activities. FDW028 evidently prolongs the survival of mice with CRC pulmonary metastases (CRPM).
| Molecular Weight | 388.46 |
| Formula | C22H24N6O |
| CAS Number | 2768426-49-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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