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EXP-3174, also known as Losartan Carboxylic Acid, is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. EXP-3174 produced a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability.
| Molecular Weight | 436.9 |
| Formula | C22H21ClN6O2 |
| CAS Number | 124750-92-1 |
| Solubility (25°C) | DMSO: ≥ 15 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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