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EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.
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Source | Front Mol Neurosci (2017). Figure 3. EUK-134 |
| Method | Determination of Mitochondrial Superoxide Generation | |
| Cell Lines | Neurons | |
| Concentrations | 20 μM | |
| Incubation Time | 2 h | |
| Results | In agreement with these findings, cultures pre-incubated for 2 h with the mito-protector agent EUK-134 (20 μM) exhibited a significant decrease in neuronal superoxide levels following AbOs addition, as observed in the pseudo color images shown in Figure 3D. |
| Molecular Weight | 416.74 |
| Formula | C18H18ClMnN2O4 |
| CAS Number | 81065-76-1 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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