All AbMole products are for research use only, cannot be used for human consumption.
Etoposide (VP-16-213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. Etoposide caused an increase in the mean fluorescence intensity of FasR in both subclones, and an induction of FasL in the ES subclone. Etoposide phosphate is rapidly absorbed and converted to etoposide. Bioavailability averages 68% at doses up to 150 mg/m2/day.
Biologics. 2025 Mar 18;19:113-123.
Targeting DNA Topoisomerase IIα in Retinoblastoma: Implications in EMT and Therapeutic Strategies
Etoposide purchased from AbMole
BMC Biol. 2024 Nov 26;22(1):273.
A novel human protein-coding locus identified using a targeted RNA enrichment technique
Etoposide purchased from AbMole
BMC Biol. 2023 Nov 24;21(1):271.
Evidence for widespread existence of functional novel and non-canonical human transcripts
Etoposide purchased from AbMole
Chem Biol Drug Des. 2022 Jan;99(1):92-102.
Identification of novel topoisomerase II alpha inhibitors by virtual screening, molecular docking, and bioassay
Etoposide purchased from AbMole
BMC Biol. 2021 May 20;19(1):108.
Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans
Etoposide purchased from AbMole
Sci Rep. 2020 Feb 4;10(1):1794.
A CRISPR/Cas13-based Approach Demonstrates Biological Relevance of Vlinc Class of Long Non-Coding RNAs in Anticancer Drug Response
Etoposide purchased from AbMole
Nat Commun. 2019 Dec 20;10(1):5799.
Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells.
Etoposide purchased from AbMole
Gene. 2015 May 10;117-27.
Identification of ADAM10 and ADAM17 with potential roles in the spermatogenesis of the Chinese mitten crab, Eriocheir sinensis.
Etoposide purchased from AbMole
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Source | Gene (2015) . Figure .etoposide (Abmole, Shanghai, China) |
| Method | Real time PCR and Western blot | |
| Cell Lines | tissue(testis) | |
| Concentrations | 0, 30, 60, 90, 120 μM | |
| Incubation Time | 0, 6, 12, 18, and 24 h | |
| Results | "Es-ADAM10 may be involved in the defense process in vivo at low etoposide concentrations, by the inhibition of spermatid apoptosis. However, Es-ADAM10 might also participate in the regulation of sperm quality. The Es-ADAM10 protein accumulated with etoposide concentration increasing (Fig. 8B). In addition, Es-ADAM10 reached peak at both the mRNA (Fig. 8C) and protein (Fig. 8D) levels after 12 h with 90 μM etoposide, indicating that etoposide induced EsADAM10 in a time- and concentration-dependent manner." |
| Molecular Weight | 588.56 |
| Formula | C29H32O13 |
| CAS Number | 33419-42-0 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage | -20°C, protect from light, sealed |
[2] K R Hande. Etoposide: four decades of development of a topoisomerase II inhibitor
[3] N C Phillips. Oral etoposide
| Related Topoisomerase Products |
|---|
| Amonafide
Amonafide is a unique ATP-independent Topo II inhibitor that is being studied in the treatment of cancer. |
| Idarubicin
Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells. |
| Dexrazoxane hydrochloride
Dexrazoxane HCl (ICRF-187, ADR-529, DXZ) is an iron chelator that can be used to prevent DOX-induced cardiotoxicity. |
| Irinotecan Hydrochloride Trihydrate
Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I. |
| Topotecan hydrochloride
Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. |
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Products are for research use only. Not for human use. We do not sell to patients.
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