All AbMole products are for research use only, cannot be used for human consumption.
Etomoxir is a potent inhibitor of carnitine palmitoyltransferase-I (CPT-1). Etomoxir binds irreversibly to the catalytic site of CPT-1 inhibiting its activity, but also upregulates fatty acid oxidation enzymes.
In vivo, Rats treated with Etomoxir (injected daily for 8 days at 20 mg/kg of body mass) display a 44% reduced cardiac CPT-I activity. The treatment of Lewis rats for 8 days with 20 mg/kg Etomoxir does not alter blood glucose, which is in line with comparable etomoxir-feeding studies.
Patent. CN116492329A 2023 Jul 28.
Patent. CN116492329A
Etomoxir purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | SF188 glioblastoma cells |
| Preparation method | Cells were harvested and suspended at 1 × 10^6 cells/ml in phosphate buffered saline (PBS) supplementedwith 25 mM glutamine and 6 mM L-glutamine. They were and treated with 1 mM etomoxir for 25 minutes. |
| Concentrations | 1 mM |
| Incubation time | 25 minutes |
| Animal Experiment | |
|---|---|
| Animal models | Male BALB/c nude mice |
| Formulation | Not mentioned |
| Dosages | 40 mg/kg |
| Administration | Intraperitoneal injection |
| Molecular Weight | 326.82 |
| Formula | C17H23ClO4 |
| CAS Number | 124083-20-1 |
| Solubility (25°C) | DMSO: ≥ 40 mg/mL |
| Storage | -20°C, protect from light, sealed |
| Related PPAR Products |
|---|
| WY 14643 (Pirinixic Acid)
WY 14643 (Pirinixic Acid) is a potent and selective, peroxisome proliferator-activated receptor-α (PPARα) agonist. |
| Rosiglitazone
Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50=60 nM, Kd=40 nM). Rosiglitazone is an TRPC5 activator (EC50=30 μM) and TRPM3 inhibitor. |
| GSK 3787
GSK3787 is an orally available selective peroxisome proliferator-activated receptor δ (PPARδ) antagonist (pIC50 = 6.6). |
| Rosiglitazone maleate
Rosiglitazone maleate (Avandia) is a potent and selective PPARγ ligand that binds to the PPARγ ligand-binding domain with a Kd value of 43 nM. |
| Ciprofibrate
Ciprofibrate is a peroxisome proliferator-activated receptor α (PPARα) agonist. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
