All AbMole products are for research use only, cannot be used for human consumption.
Esomeprazole sodium (Nexium) is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg. Esomeprazole sodium (Nexium) suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. Esomeprazole sodium (Nexium) is used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease and Zollinger-Ellison syndrome. Esomeprazole is the S-enantiomer of omeprazole. The S- and R-isomers of omeprazole are protonated and converted in the acidic compartment of the parietal cell forming the active inhibitor, the achiral sulphenamide. By acting specifically on the proton pump, esomeprazole blocks the final step in acid production, thus reducing gastric acidity. This effect is dose-related up to a daily dose of 20 to 40 mg and leads to inhibition of gastric acid secretion.
| Molecular Weight | 367.4 |
| Formula | C17H18N3O3S.Na |
| CAS Number | 161796-78-7 |
| Solubility (25°C) | DMSO 70 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Proton Pump Products |
|---|
| Omeprazole
Omeprazol is a first-in-class proton pump inhibitor (PPI) used in the treatment of dyspepsia, laryngopharyngeal reflux (LPR) and Zollinger–Ellison syndrome. |
| Dexlansoprazole
Dexlansoprazole, the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties. |
| Tenatoprazole
Tenatoprazole is a procompound of the proton pump inhibitor (PPI) class, which inhibits proton transport with IC50 of 3.2 μM. |
| Esomeprazole Magnesium
Esomeprazole Magnesium is a proton pump inhibitor to reduce gastric acid secretion. |
| Rabeprazole Sodium
Rabeprazole is a frequently used second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
