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ES936

Cat. No. M8356

All AbMole products are for research use only, cannot be used for human consumption.

ES936 Structure

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Quality Control & Documentation
Biological Activity

ES936 is a very potent and selective inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1). ES936 inhibits superoxide scavenging by NQO1 in tumor and cardiovascular cells. NQO1 is highly expressed in pancreatic cancers, and ES936 inhibits proliferation of pancreatic tumor lines Mia PaCa and BxPC-3 with nanomolar IC50 values.

Chemical Information
Molecular Weight 356.33
Formula C18H16N2O6
CAS Number 192820-78-3
Solubility (25°C) DMSO: 2 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] David Gonzlez-Aragn, et al. ES936 stimulates DNA synthesis in HeLa cells independently on NAD(P)H:quinone oxidoreductase 1 inhibition, through a mechanism involving p38 MAPK

[2] Donna L Dehn, et al. 5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo

[3] Wenchang Guo, et al. Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition

[4] Donna L Dehn, et al. Biochemical, cytotoxic, and genotoxic effects of ES936, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, in cellular systems

[5] S L Winski, et al. Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches

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Keywords: ES936 supplier, inhibitors, activators

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