All AbMole products are for research use only, cannot be used for human consumption.
Erlotinib (CP-358774) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer.
Sci Rep. 2017 May 8;7(1):1578.
Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wallmediated lipolysis, inflammation and dysglycemia
Erlotinib (CP-358774) purchased from AbMole
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Source | Sci Rep (2017). Figure 1. Erlotinib (AbMole Bioscience, Houston, TX) |
| Method | bacterial cell wall-induced lipolysis | |
| Cell Lines | Murine 3T3-L1 preadipocytes | |
| Concentrations | 1–10 μM | |
| Incubation Time | 48 h | |
| Results | FK565-stimulated glycerol release was lower in 3T3-L1 adipocytes pre-incubated with TKIs ponatinib, dasatinib, dafabranib, vandetanib, ruxolitinib, SB203580, ibrutinib, gefitinib, sorafenib, neratinib, erlotinib, at 1–10 μM. |
| Molecular Weight | 393.44 |
| Formula | C22H23N3O4 |
| CAS Number | 183321-74-6 |
| Solubility (25°C) | DMSO 20 mg/mL (May need ultrasonic and warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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Erlotinib is an inhibitor of human EGFR tyrosine kinase (IC50 = 2 nM) and decreases EGFR autophosphorylation in tumor cells (IC50 = 20 nM). |
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