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ER 819762

Cat. No. M6716

All AbMole products are for research use only, cannot be used for human consumption.

ER 819762 Structure

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Quality Control & Documentation
Biological Activity

ER 819762 is a potent EP4 receptor antagonist (IC50 = 59 nM). Suppresses EP4-mediated Th1 differentiation, Th17 cell expansion, and IL-23 secretion by activated dendritic cells. Inhibits Th1 and Th17 cytokine production, suppresses collagen- and GPI-induced arthritis in mice. Attenuates CFA-induced inflammatory pain in rats. Analgesic. Orally bioavailable.

Chemical Information
Molecular Weight 489.65
Formula C30H39N3O3
CAS Number 1155773-15-1
Solubility (25°C) DMSO 0.98 mg/mL (with gentle warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hansen, et al. Mol Pharmacol. Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea].

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  Catalog
Abmole Inhibitor Catalog




Keywords: ER 819762 supplier, inhibitors, activators

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