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Epiberberine

Cat. No. M4402

All AbMole products are for research use only, cannot be used for human consumption.

Epiberberine Structure
Size Price Availability Quantity
5mg USD 88 In stock
10mg USD 110 In stock
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Quality Control & Documentation
Biological Activity

Epiberberine is a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine is also a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean).

Chemical Information
Molecular Weight 336.36
Formula C20H18NO4
CAS Number 6873-09-2
Solubility (25°C) DMSO 9 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hang Ma, et al. Drug Dev Res. Antihyperglycemia and Antihyperlipidemia Effect of Protoberberine Alkaloids From Rhizoma Coptidis in HepG2 Cell and Diabetic KK-Ay Mice

[2] Jae Sue Choi, et al. Arch Pharm Res. Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways

[3] Hyun Ah Jung, et al. Biol Pharm Bull. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids

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Keywords: Epiberberine supplier, AChR/AChE, inhibitors, activators

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