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Englerin A 

Cat. No. M27785

All AbMole products are for research use only, cannot be used for human consumption.

Englerin A  Structure

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Quality Control & Documentation
Biological Activity

Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload.

Chemical Information
Molecular Weight 442.54
Formula C26H34O6
CAS Number 1094250-15-3
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Tiago Rodrigues, et al. Angew Chem Int Ed Engl. Unveiling (-)-Englerin A as a Modulator of L-Type Calcium Channels

[2] Suat Peng Neo, et al. J Proteome Res. Englerin A Rewires Phosphosignaling via Hsp27 Hyperphosphorylation to Induce Cytotoxicity in Renal Cancer Cells

[3] Florian J Sulzmaier, et al. PLoS One. Englerin a selectively induces necrosis in human renal cancer cells

[4] Sarath P D Seenadera, et al. ACS Med Chem Lett. Biological Effects of Modifications of the Englerin A Glycolate

[5] João de Sousa Valente, et al. Int J Mol Sci. (-)-Englerin-A Has Analgesic and Anti-Inflammatory Effects Independent of TRPC4 and 5

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Abmole Inhibitor Catalog




Keywords: Englerin A  supplier, TRP Channel, inhibitors, activators

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