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Enfortumab (anti-Nectin-4)

Cat. No. M21436

All AbMole products are for research use only, cannot be used for human consumption.

Enfortumab (anti-Nectin-4)  Structure

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Quality Control & Documentation
Biological Activity

Enfortumab anti-Nectin-4 is a monoclonal antibody targeting Nectin-4 that acts as an ADC to initiate the internalization of the ADc-Nectin-4 complex and the hydrolyzed cleavage of Monomethylaustatin E (MMAE), The microtubule network was damaged to induce apoptosis. Enfortumab anti-Nectin-4 can be used to study urothelial cancer.

Chemical Information
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Olivier Cabaud, et al. Mol Cancer Ther. Overcoming Resistance to Anti-Nectin-4 Antibody-Drug Conjugate

[2] Wafa Bouleftour, et al. Mol Cancer Ther. The Anti-Nectin 4: A Promising Tumor Cells Target. A Systematic Review

[3] Elisabeth I Heath, et al. Nat Rev Urol. The biology and rationale of targeting nectin-4 in urothelial carcinoma

[4] Zachery Halford, et al. Ann Pharmacother. Enfortumab Vedotin-ejfv: A First-in-Class Anti-Nectin-4 Antibody-Drug Conjugate for the Management of Urothelial Carcinoma

[5] Pia M Challita-Eid, et al. Cancer Res. Enfortumab Vedotin Antibody-Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models

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Keywords: Enfortumab (anti-Nectin-4) supplier, Apoptosis, inhibitors, activators

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