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Enavogliflozin

Cat. No. M21456

All AbMole products are for research use only, cannot be used for human consumption.

Enavogliflozin Structure
Synonym:

DWP-16001

Size Price Availability Quantity
5mg USD 440 In stock
10mg USD 690 In stock
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Quality Control & Documentation
Biological Activity

Enavogliflozin (DPW-16001), an antidiabetic compound, is a first class selective sodium-glucose cotransporter-2 (SGLT-2) inhibitor with oral activity.

Chemical Information
Molecular Weight 446.92
Formula C24H27ClO6
CAS Number 1415472-28-4
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Min-Soo Kim, et al. Pharmaceutics. Physiologically Based Pharmacokinetic Modelling to Predict Pharmacokinetics of Enavogliflozin, a Sodium-Dependent Glucose Transporter 2 Inhibitor, in Humans

[2] Soo Heon Kwak, et al. Diabetes Obes Metab. Efficacy and safety of enavogliflozin, a novel SGLT2 inhibitor, in Korean people with type 2 diabetes: A 24-week, multicentre, randomized, double-blind, placebo-controlled, phase III trial

[3] Minyeong Pang, et al. Pharmaceutics. Pharmacokinetics and Tissue Distribution of Enavogliflozin in Mice and Rats

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Canagliflozin

Canagliflozin is a potent, selective sodium glucose co-transporter 2 inhibitor.

Empagliflozin

Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6.

Phloridzin

Phloridzin is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.

Phloretin

Phloretin (NSC 407292; RJC 02792) is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2).

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Keywords: Enavogliflozin, DWP-16001 supplier, SGLT, inhibitors, activators

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