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Emtricitabine (Emtriva) is a nucleoside reverse transcriptase inhibitor with an IC50 of 27.7 μM.The compound works by inhibiting reverse transcriptase, the enzyme that copies HIV RNA into new viral DNA. By interfering with this process, which is central to the replication of HIV, emtricitabine can help to lower the amount of HIV, or "viral load", in a patient’s body and can indirectly increase the number of immune system cells (called T cells or CD4+ T-cells). Both of these changes are associated with healthier immune systems and decreased likelihood of serious illness.
| Molecular Weight | 247.25 |
| Formula | C8H10FN3O3S |
| CAS Number | 143491-57-0 |
| Solubility (25°C) | DMSO 60 mg/mL Water 15 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Abdulrahman A Al-Majed, et al. Emtricitabine
[5] Emma D Deeks. Bictegravir/Emtricitabine/Tenofovir Alafenamide: A Review in HIV-1 Infection
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