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Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6.
| Cell Experiment | |
|---|---|
| Cell lines | HK-2 cells |
| Preparation method | Cellular Apoptotic Assay In the terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) assay, HK-2 cells incubated for 24 h in the presence or absence of empagliflozin were fixed in 4% paraformaldehyde and treated with a blocking solution (10% FBS in PBS) for 30 min at 25 °C. Cells were permeabilized with 0.1% (v/v) Triton X-100 in PBS, followed by incubation with the TUNEL reaction mixture for 1 h at 37 °C. After the treatment, the cells were observed under a fluorescence microscope. |
| Concentrations | 100 and 500 nM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Male C57BL/6J mice (10 weeks of age) |
| Formulation | dissolved in hydroxy ethyl cellulose (HEC) |
| Dosages | 3 or 10 mg/kg |
| Administration | oral gavage |
| Molecular Weight | 450.91 |
| Formula | C23H27ClO7 |
| CAS Number | 864070-44-0 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related SGLT Products |
|---|
| Dapagliflozin
Dapagliflozin (BMS-512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2). |
| Canagliflozin
Canagliflozin is a potent, selective sodium glucose co-transporter 2 inhibitor. |
| Phloridzin
Phloridzin is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor. |
| Phloretin
Phloretin (NSC 407292; RJC 02792) is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). |
| Sotagliflozin
Sotagliflozin (LX-4211) is an orally active, first-in-class dual SGLT1/2 inhibitor with IC50s of 36 nM and 1.8 nM, respectively, and is used in studies related to type 1 diabetes and heart failure. |
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