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Emapticap pegol

Cat. No. M31400

All AbMole products are for research use only, cannot be used for human consumption.

Emapticap pegol Structure
Synonym:

NOX-E36

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Quality Control & Documentation
Biological Activity

Emapticap pegol (NOX-E36) is a 40-nucleotide oligonucleotide aptamer and specific inhibitor of the pro-inflammatory chemokine C-C motif-ligand 2 (CCL2), with distinct forms of Spiegelmers (L-RNA aptamers) in human (NOX-E36) and mouse (mNOX-E36).

Chemical Information
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Margien G S Boels, et al. Am J Pathol. Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy

[2] Dominik Oberthür, et al. Nat Commun. Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2

[3] Axel Vater, et al. Drug Discov Today. Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer(®) therapeutics

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Keywords: Emapticap pegol, NOX-E36 supplier, inhibitors, activators

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