All AbMole products are for research use only, cannot be used for human consumption.
Ellagic acid is a natural antioxidant as well as a potent, ATP-competitive inhibitor of CK2 and SHP2 with IC50 and Ki values of 40 nM and 20 nM, respectively.In addition, Ellagic acid exhibits antiproliferative activity and inhibition of topoisomerase II (Topoisomerase II).
| Cell Experiment | |
|---|---|
| Cell lines | Peripheral blood mononuclear cells (PBMCs) |
| Preparation method | Cells were cultured in a humidified incubator maintained at 37 °C and 5% CO2 atmosphere with or without known concentrations of caffeic acid, ellagic acid and ferulic acid for 18 h. Cell viability was assayed by trypan exclusion method. |
| Concentrations | 100 and 200 μM |
| Incubation time | 18 h |
| Animal Experiment | |
|---|---|
| Animal models | Sprague-Dawley rat |
| Formulation | DMSO |
| Dosages | 75 mg/kg |
| Administration | IP injections |
| Molecular Weight | 302.19 |
| Formula | C14H6O8 |
| CAS Number | 476-66-4 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Jasmina Djedjibegovic, et al. Ellagic Acid-Derived Urolithins as Modulators of Oxidative Stress
[4] Giuseppe Derosa, et al. Ellagic Acid and Its Role in Chronic Diseases
| Related Topoisomerase Products |
|---|
| Amonafide
Amonafide is a unique ATP-independent Topo II inhibitor that is being studied in the treatment of cancer. |
| Idarubicin
Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells. |
| Dexrazoxane hydrochloride
Dexrazoxane HCl (ICRF-187, ADR-529, DXZ) is an iron chelator that can be used to prevent DOX-induced cardiotoxicity. |
| Irinotecan Hydrochloride Trihydrate
Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I. |
| Topotecan hydrochloride
Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
