Free shipping on all orders over $ 500

Elezanumab

Cat. No. M24799

All AbMole products are for research use only, cannot be used for human consumption.

Elezanumab Structure
Synonym:

ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody

Price and Availability

For this product's availability, delivery time and price, please email inquiry@abmole.com directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC50 around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism.

Chemical Information
CAS Number 1791416-49-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Peer B Jacobson, et al. Transl Stroke Res. Neutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery Occlusion

[2] Hari V Kalluri, et al. Ann Neurol. Phase 1 Evaluation of Elezanumab (Anti-Repulsive Guidance Molecule A Monoclonal Antibody) in Healthy and Multiple Sclerosis Participants

[3] Andrea J Mothe, et al. Neurobiol Dis. Delayed administration of elezanumab, a human anti-RGMa neutralizing monoclonal antibody, promotes recovery following cervical spinal cord injury

[4] Peer B Jacobson, et al. Neurobiol Dis. Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates

Related TGF-beta/Smad Products
Pirfenidone

Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells. Pirfenidone (AMR69) attenuates CCL2 and CCL12 production in fibrocyte cells.

Asiaticoside

Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica.
Amygdalin

Laetrile is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds.
Norcantharidin

Norcantharidin
Kartogenin

Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
  Catalog
Abmole Inhibitor Catalog




Keywords: Elezanumab, ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody supplier, TGF-beta/Smad, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.