All AbMole products are for research use only, cannot be used for human consumption.
Eldecalcitol is an analog of 1,25-dihydroxyvitamin D3 that improves bone mineral density. Eldecalcitol is orally bioactive, which binds to vitamin D receptors and binding protein for the goal of achieving greater specificity to bind calcium for its absorption. This greater affinity is 2.7-fold that of the active vitamin D form of calcitriol. Eldecalcitol (0-50 nM; 24 h) displays no cytotoxicity, and (0.5-50 nM; 24 h) reduces cell death induced by LPS (5 μg/mL). Eldecalcitol (5 nM; 24 h) inhibits the LPS-induced pyroptosis by activating Nrf2 and its effector molecule HO-1. Eldecalcitol (0.5-50 nM; 24 h) exhibits anti-pyroptotic ability, and decreases NLRP3, caspase-1, and IL-1β expression dose-dependently. Eldecalcitol (0.04-40 nM; 0-48 h) inhibits the proliferation and migration of SCC-15 and CAL-27 cells.
| Molecular Weight | 490.72 |
| Formula | C30H50O5 |
| CAS Number | 104121-92-8 |
| Solubility (25°C) | Methanol 8 mg/mL DMSO 3 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | 4°C, protect from light, sealed |
[3] Yuko Noguchi, et al. Eldecalcitol for the treatment of osteoporosis
[4] T Matsumoto, et al. Eldecalcitol for the treatment of osteoporosis
[5] Mark Sanford, et al. Eldecalcitol: a review of its use in the treatment of osteoporosis
| Related Vitamin Products |
|---|
| Calcifediol
Calcifediol is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase. |
| Vitamin C (L-Ascorbic Acid)
Vitamin C (L-Ascorbic Acid) is a water-soluble vitamin indicated for the prevention and treatment of scurvy. |
| Lipoic acid
Lipoic acid is a class of compounds belonging to the B class vitamins and is the growth factor of yeast and some kinds of microorganisms. |
| Paricalcitol
Paricalcitol, an analog of 1,25-dihydroxyvitamin D3 with lower calcemic activity, against uterine fibroids using in vitro and in vivo evaluations in appropriate uterine fibroid cells and animal models. |
| Tacalcitol
Tacalcitol is a synthetic vitamin D3 analog. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
