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Elafibranor (also known as GFT-505) is a dual PPARα/δ agonist with EC50s of 45 and 175 nM, respectively. Elafibranor (GFT505) treatment improves glucose control and plasma lipids in diabetic db/db mice. A significant dose-dependent reduction of hepatic expression of the key gluconeogenic enzymes glucose 6-phosphatase (G6Pase), PEPCK, and fructose 1,6-bisphosphatase 1 (FBP1) is observed with Elafibranor.
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| Cell lines | |
| Preparation method | |
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| Incubation time | |
| Animal Experiment | |
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| Animal models | Male db/db and db/lean mice |
| Formulation | 0.1% Tween 80 and 1% carboxymethylcellulose in 98.9% distilled water |
| Dosages | 3, 10 and 30 mg/kg/day |
| Administration | oral gavage |
| Molecular Weight | 384.49 |
| Formula | C22H24O4S |
| CAS Number | 923978-27-2 |
| Solubility (25°C) | DMSO ≥ 33 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PPAR Products |
|---|
| WY 14643 (Pirinixic Acid)
WY 14643 (Pirinixic Acid) is a potent and selective, peroxisome proliferator-activated receptor-α (PPARα) agonist. |
| Rosiglitazone
Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50=60 nM, Kd=40 nM). Rosiglitazone is an TRPC5 activator (EC50=30 μM) and TRPM3 inhibitor. |
| GSK 3787
GSK3787 is an orally available selective peroxisome proliferator-activated receptor δ (PPARδ) antagonist (pIC50 = 6.6). |
| Rosiglitazone maleate
Rosiglitazone maleate (Avandia) is a potent and selective PPARγ ligand that binds to the PPARγ ligand-binding domain with a Kd value of 43 nM. |
| Ciprofibrate
Ciprofibrate is a peroxisome proliferator-activated receptor α (PPARα) agonist. |
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Products are for research use only. Not for human use. We do not sell to patients.
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